Interspecies communication in the gut, from bacterial delivery to host-cell response Journal Article

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Authors: Hodges, K.; Hecht, G
Article Title: Interspecies communication in the gut, from bacterial delivery to host-cell response
Abstract: Intestinal pathogens have a wide variety of strategies for communicating with host epithelial cells. This review highlights a few key examples of those strategies. Enteropathogenic Escherichia coli (EPEC) use a type III secretion system (T3SS) to alter host ion transport through both transcriptional and post-translational mechanisms. Salmonella use a similar T3SS to invade host cells and modify an intracellular vacuole, which also impacts host vesicle trafficking. Helicobacter pylori use host cell integrins to provide a conformational change which drives the type IV secretion system into the host cell for delivery of CagA. The novel type VI section systems are phage-like apparati that deliver VgrG-1, which causes actin cross-linking and fluid accumulation in a suckling mouse model. An entirely different delivery mechanism is the outer membrane vesicle (OMV) which is composed of bacterial outer membrane wrapped around contents of the periplamsic space. Enterotoxigenic E. coli use OMVs to deliver bundles of heat labile enterotoxin to host cells. Finally we discuss the host responses to these varied methods of communication.
Journal Title: The Journal of physiology
Volume: 590
Issue: Pt 3
ISSN: 1469-7793; 0022-3751
Publisher: Unknown  
Journal Place: England
Date Published: 2012
Start Page: 433
End Page: 440
Language: eng
DOI/URL:

10.1113/jphysiol.2011.220822
Notes: LR: 20131016; JID: 0266262; 0 (Bacterial Proteins); 0 (Bacterial Toxins); OID: NLM: PMC3379691; 2011/11/21 [aheadofprint]; ppublish