Bacterial infections of the small intestine Journal Article

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Authors: Hodges, K.; Hecht, G
Article Title: Bacterial infections of the small intestine
Abstract: PURPOSE OF REVIEW: The purpose of this study is to summarize the recent developments in small intestinal bacterial infections. RECENT FINDINGS: This review focuses on aspects of intestinal bacterial infection concerning research developments related to pathogenesis, new therapeutic agents and approaches, as well as potential new vaccine targets. SUMMARY: In terms of drug utilization, azithromycin was successfully used to eradicate a Shiga toxin producing Escherichia coli (enterohemorrhagic E. coli) without harmful effects. In the case of Clostridium difficile, fidaxomicin was found to be comparable to or superior to vancomycin depending on study conditions and whether there was concomitant antibiotic use. A novel research finding is the role of galectin 8, which is a danger-sensing lectin, which plays a role in targeting Salmonella for autophagy. In addition, several enteropathogenic E. coli and Shigella effectors were found to inactivate members of the nuclear factor kappa B pathway.
Journal Title: Current opinion in gastroenterology
Volume: 29
Issue: 2
ISSN: 1531-7056; 0267-1379
Publisher: Unknown  
Journal Place: United States
Date Published: 2013
Start Page: 159
End Page: 163
Language: eng
DOI/URL:

10.1097/MOG.0b013e32835b422c
Notes: GR: DK050694 15A1/DK/NIDDK NIH HHS/United States; GR: DK067887 05S1/DK/NIDDK NIH HHS/United States; GR: DK58964/DK/NIDDK NIH HHS/United States; GR: I01 BX000785/BX/BLRD VA/United States; GR: R01 DK050694/DK/NIDDK NIH HHS/United States; GR: R01 DK097043/DK/NIDDK NIH HHS/United States; JID: 8506887; 0 (Anti-Bacterial Agents); ppublish