Interactions of oversulfated chondroitin sulfate (OSCS) from different sources with unfractionated heparin. Journal Article

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Authors: Gray, A; Litinas, E.; Jeske, W; Fareed, J; Hoppensteadt, D
Article Title: Interactions of oversulfated chondroitin sulfate (OSCS) from different sources with unfractionated heparin.
Abstract: In 2008, oversulfated chondroitin sulfate (OSCS) was identified as the main contaminant in recalled heparin. Oversulfated chondroitin sulfate can be prepared from bovine (B), porcine (P), shark (Sh), or skate (S) origin and may produce changes in the antithrombotic, bleeding, and hemodynamic profile of heparins. This study examines the interactions of various OSCSs on heparin in animal models of thrombosis and bleeding, as well as on the anticoagulant and antiprotease effects in in vitro assays. Mixtures of 70% unfractionated heparin (UFH) with 30% OSCS from different sources were tested. In the in vitro activated partial thromboplastin time (aPTT) assay, all contaminant mixtures showed a decrease in clotting times. In addition, a significant increase in bleeding time compared to the control (UFH/saline) was observed. In the thrombosis model, no significant differences were observed. The OSCSs significantly increased anti-Xa activity in ex vivo blood samples. These results indicate that various sources of OSCS affect the hemostatic properties of heparin.
Journal Title: Clinical Applied Thrombosis/Hemostasis
Volume: 18
Issue: 2
ISSN: 1938-2723
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: 166
End Page: 173
Language: English
DOI/URL:

http://ovidsp.ovid.com/ovidweb.cgi?T=JS=Y=N=fulltext=medl=22311630

http://hn9yf5lh6v.search.serialssolutions.com/?url_ver=Z39.88-2004=info:ofi/fmt:kev:mtx:journal=info:sid/Ovid:medl=article=info:doi/=info:pmid/22311630=1076-0296=18=2=166=166-73=2012=Clinical+%26+Applied+Thrombosis%2FHemostasis=Interactions+of+oversulfated+chondroitin+sulfate+%28OSCS%29+from+different+sources+with+unfractionated+heparin.=Gray
Notes: ID: 12446; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: dav, 9508125; CAS Registry/EC Number/Name of Substance: 0 (Anticoagulants). 0 (Fibrinolytic Agents). 0 (Sulfates). 0 (Tissue Extracts). 9001-26-7 (Prothrombin). 9002-04-4 (Factor IIa). 9005-49-6 (Heparin). 9007-28-7 (Chondroitin Sulfates). EC 3-4-21-6 (Factor Xa).; Electronic Date of Publication: 20120206; Entry Date: 20120716