Feasibility of conjunctival hemodynamic measurements in rabbits: reproducibility, validity, and response to acute hypotension. Journal Article

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Authors: Gaynes, B; Teng, P. Y.; Wanek, J; Shahidi, M
Article Title: Feasibility of conjunctival hemodynamic measurements in rabbits: reproducibility, validity, and response to acute hypotension.
Abstract: OBJECTIVE: To evaluate the feasibility of conjunctival hemodynamic measurements based on assessment of reproducibility, validity, and response to acute hypotension. METHODS: Image sequences of the conjunctival microvasculature of rabbits were captured using a slit lamp biomicroscope under a steady-state condition, after topical administration of phenylephrine, and after intravenous administration of esmolol. Venous hemodynamic parameters (diameter, blood velocity, blood flow, and wall shear stress) were derived. RESULTS: Conjunctival venous diameters ranged from 9 to 34 um and blood velocities ranged from 0.08 to 0.95 mm/s. Coefficients of variation of venous diameter and blood velocity measurements were, on average, 6% and 14%, respectively. Automated and manual measurements of venous diameter and velocity were highly correlated (R = 0.97; p = 0.52; p = 0.01). CONCLUSIONS: The feasibility of quantifying alterations in microvascular hemodynamics in the bulbar conjunctiva was established. The method is of potential value in evaluating microcirculatory hemodynamics related to cardiovascular function. 2012 John Wiley Sons Ltd.
Journal Title: Microcirculation
Volume: 19
Issue: 6
ISSN: 1073-9688
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: 521
End Page: 529
Language: English
DOI/URL:

http://hn9yf5lh6v.search.serialssolutions.com/?url_ver=Z39.88-2004=info:ofi/fmt:kev:mtx:journal=info:sid/Ovid:medl=article=info:doi/10.1111%2Fj.1549-8719.2012.00182.x=info:pmid/22486988=1073-9688=19=6=521=521-9=2012=Microcirculation=Feasibility+of+conjunctival+hemodynamic+measurements+in+rabbits%3A+reproducibility%2C+validity%2C+and+response+to+acute+hypotension.=Gaynes

http://dx.doi.org/10.1111/j.1549-8719.2012.00182.x
Notes: ID: 12657; Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Internet; NLM Journal Code: cg2, 9434935; Grant Number: P30 EY001792 (United States NEI NIH HHS), P30 EY01792 (United States NEI NIH HHS), R01 EY17918 (United States NEI NIH HHS)