The prevalence and extent of gastroesophageal reflux disease correlates to the type of lung transplantation. Journal Article


Authors: Fisichella, P. M.; Davis, C. S.; Shankaran, V.; Gagermeier, J.; Dilling, D; Alex, C. G.; Kovacs, E. J.; Joehl, R. J.; Love, R. B.
Article Title: The prevalence and extent of gastroesophageal reflux disease correlates to the type of lung transplantation.
Abstract: BACKGROUND: Evidence is increasingly convincing that lung transplantation is a risk factor of gastroesophageal reflux disease (GERD). However, it is still not known if the type of lung transplant (unilateral, bilateral, or retransplant) plays a role in the pathogenesis of GERD. STUDY DESIGN: The records of 61 lung transplant patients who underwent esophageal function tests between September 2008 and May 2010, were retrospectively reviewed. These patients were divided into 3 groups based on the type of lung transplant they received: unilateral (n=25); bilateral (n=30), and retransplant (n=6). Among these groups we compared: (1) the demographic characteristics (eg, sex, age, race, and body mass index); (2) the presence of Barrett esophagus, delayed gastric emptying, and hiatal hernia; and (3) the esophageal manometric and pH-metric profile. RESULTS: Distal and proximal reflux were more prevalent in patients with bilateral transplant or retransplant and less prevalent in patients after unilateral transplant, regardless of the cause of their lung disease. The prevalence of hiatal hernia, Barrett esophagus, and the manometric profile were similar in all groups of patients. CONCLUSIONS: Although our data show a discrepancy in prevalence of GERD in patients with different types of lung transplantation, we cannot determine the exact cause for these findings from this study. We speculate that the extent of dissection during the transplant places the patients at risk for GERD. On the basis of the results of this study, a higher level of suspicion of GERD should be held in patients after bilateral or retransplantation.
Journal Title: Surgical laparoscopy, endoscopy percutaneous techniques
Volume: 22
Issue: 1
ISSN: 1534-4908; 1530-4515
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: 46
End Page: 51
Language: English
DOI/URL:
Notes: ID: 12208; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Internet; NLM Journal Code: 100888751, dd2; CAS Registry/EC Number/Name of Substance: 0 (Contrast Media). 0 (Radiopharmaceuticals). 0 (Technetium Tc 99m Sulfur Colloid). 7727-43-7 (Barium Sulfate).; Entry Date: 20120416
LUC Authors
  1. Daniel Dilling
    34 Dilling
  2. Elizabeth Kovacs
    66 Kovacs
Related LUC Article