Cholinergic regulation of keratinocyte innate immunity and permeability barrier integrity: new perspectives in epidermal immunity and disease Journal Article

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Authors: Curtis, B. J.; Radek, K. A.
Article Title: Cholinergic regulation of keratinocyte innate immunity and permeability barrier integrity: new perspectives in epidermal immunity and disease
Abstract: Several cutaneous inflammatory diseases and their clinical phenotypes are recapitulated in animal models of skin disease. However, the identification of shared pathways for disease progression is limited by the ability to delineate the complex biochemical processes fundamental for development of the disease. Identifying common signaling pathways that contribute to cutaneous inflammation and immune function will facilitate better scientific and therapeutic strategies to span a variety of inflammatory skin diseases. Aberrant antimicrobial peptide (AMP) expression and activity is one mechanism behind the development and severity of several inflammatory skin diseases and directly influences the susceptibility of skin to microbial infections. Our studies have recently exposed a newly identified pathway for negative regulation of AMPs in the skin by the cholinergic anti-inflammatory pathway via acetylcholine (ACh). The role of ACh in AMP regulation of immune and permeability barrier function in keratinocytes is reviewed, and the importance for a better comprehension of cutaneous disease progression by cholinergic signaling is discussed.
Journal Title: Journal of Investigative Dermatology
Volume: 132
Issue: 1
ISSN: 1523-1747
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: 28
End Page: 42
Language: English
DOI/URL:

http://ovidsp.ovid.com/ovidweb.cgi?T=JS=Y=N=fulltext=medl=21918536

http://dx.doi.org/10.1038/jid.2011.264
Notes: ID: 12108; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; [Review]; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: ihz, 0426720; CAS Registry/EC Number/Name of Substance: 51-84-3 (Acetylcholine).; Grant Number: 1P30AA019373-01 (United States NIAAA NIH HHS), 5T32AA013527-09 (United States NIAAA NIH HHS), AI052453 (United States NIAID NIH HHS), AR45676 (United States NIAMS NIH HHS), F32-AR054220-01A2 (United States NIAMS NIH HHS), HHSN26620040029C (United States PHS HHS), N01-AI-40029AI48176 (United States NIAID NIH HHS); Electronic Date of Publication: 20110915; Entry Date: 20120207