Association of baseline urodynamic measures of urethral function with clinical, demographic, and other urodynamic variables in women prior to undergoing midurethral sling surgery Journal Article

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Authors: Chai, T. C.; Huang, L; Kenton, K.; Richter, H. E.; Baker, J; Kraus, S.; Litman, H.; Brubaker, L; Urinary Incontinence Treatment Network (UITN)
Article Title: Association of baseline urodynamic measures of urethral function with clinical, demographic, and other urodynamic variables in women prior to undergoing midurethral sling surgery
Abstract: AIMS: To explore how baseline demographic, clinical, and urodynamic (UDS) variables correlate with measures of urethral function in women planning midurethral sling surgery. METHODS: Women with predominant stress urinary incontinence (SUI) as part of the trial of mid-urethral slings (TOMUS) were characterized preoperatively including: demographics, body mass index (BMI), responses to the Medical and Epidemiologic Social Aspects of Aging (MESA) and Urogenital Distress Inventory (UDI) questionnaires, pad weight (PW), incontinence duration, prior SUI surgery, prolapse, strength of pelvic contraction, Q-tip test, uroflow, cystometrogram, and detrusor pressures at maximum flow (Pdet at Qmax). Multivariate regression analysis and modeling confirmed variables with significant correlations with maximal urethral closure pressure (MUCP), functional urethral length (FUL), and Valsalva leak point pressure (VLPP). RESULTS: Five-hundred thirty-nine women were included in the analysis. In multivariable analyses, PW (P = 0.045) and age (P 0.0001) were negatively correlated with MUCP (as PW and age increased, MUCP decreased); BMI (P = 0.02) and Pdet at Qmax (P 0.0001) were positively correlated with MUCP (as BMI and Pdet at Qmax increased, MUCP increased). Age (P = 0.002) was negatively correlated with FUL; Qtip delta (P = 0.006), pelvic organ prolapse quantification examination (POPQ) stage (P = 0.002) and strength of pelvic contraction (P = 0.03) were positively correlated with FUL. Duration of incontinence (P = 0.01) was negatively correlated with VLPP; Qtip delta (P = 0.02), BMI (P = 0.0005) and Pdet at Qmax (P = 0.0005) were positively correlated with VLPP. CONCLUSIONS: Age, BMI, Qtip delta, and Pdet at Qmax were variables that correlated with two or more measures of urethral function. These correlations may help direct future research in female urethral function.
Journal Title: Neurourology and urodynamics
Volume: 31
Issue: 4
ISSN: 1520-6777; 0733-2467
Publisher: Wiley Periodicals, Inc  
Journal Place: United States
Date Published: 2012
Start Page: 496
End Page: 501
Language: eng
DOI/URL:

10.1002/nau.21198

10.1002/nau.21198
Notes: LR: 20130520; CI: Copyright (c) 2012; GR: U01 DK 58225/DK/NIDDK NIH HHS/United States; GR: U01 DK060397/DK/NIDDK NIH HHS/United States; GR: U01 DK060397-08/DK/NIDDK NIH HHS/United States; GR: U01 DK58229/DK/NIDDK NIH HHS/United States; GR: U01 DK58231/DK/NIDDK NIH HHS/United States; GR: U01 DK58234/DK/NIDDK NIH HHS/United States; GR: U01 DK60379/DK/NIDDK NIH HHS/United States; GR: U01 DK60380/DK/NIDDK NIH HHS/United States; GR: U01 DK60393/DK/NIDDK NIH HHS/United States; GR: U01 DK60395/DK/NIDDK NIH HHS/United States; GR: U01 DK60397/DK/NIDDK NIH HHS/United States; GR: U01 DK60401/DK/NIDDK NIH HHS/United States; JID: 8303326; NIHMS310361; OID: NLM: NIHMS310361; OID: NLM: PMC3331959; 2011/02/11 [received]; 2011/07/05 [accepted]; 2012/02/29 [aheadofprint]; ppublish