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Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program's potential for national nutrition and health surveys Journal Article
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| Authors: | Cashman, K. D.; Kiely, M.; Kinsella, M.; Durazo-Arvizu, R; Tian, L; Zhang, Y; Lucey, A.; Flynn, A.; Gibney, M. J.; Vesper, H. W.; Phinney, K. W.; Coates, P. M.; Picciano, M. F.; Sempos, C. T. |
| Article Title: | Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program's potential for national nutrition and health surveys |
| Abstract: | Background: The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D 25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improve public health practice. Objective: We applied VDSP protocols to existing ELISA-derived serum 25(OH)D data from the Irish National Adult Nutrition Survey (NANS) as a case-study survey and evaluated their effectiveness by comparison of the protocol-projected estimates with those from a reanalysis of survey serums by using liquid chromatography-tandem mass spectrometry (LC-tandem MS). Design: The VDSP reference system and protocols were applied to ELISA-based serum 25(OH)D data from the representative NANS sample (n = 1118). A reanalysis of 99 stored serums by using standardized LC-tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC-tandem MS reanalyzed values for all serums. Results: Year-round prevalence rates for serum 25(OH)D concentrations 125 nmol/L were 1.2%, 0.3%, and 0.6% by means of ELISA, VDSP protocols, and LC-tandem MS, respectively. Conclusion: VDSP protocols hold a major potential for national nutrition and health surveys in terms of the standardization of serum 25(OH)D data. |
| Journal Title: | American Journal of Clinical Nutrition |
| Volume: | 97 |
| Issue: | 6 |
| ISSN: | 0002-9165 |
| Publisher: | Unknown |
| Date Published: | 2013 |
| Start Page: | 1235 |
| End Page: | 1242 |
| Language: | English |
| DOI/URL: | |
| Notes: | ID: 2012127485 |
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