Authors: |
Brubaker, L; Gousse, A.; Sand, P.; Thompson, C; Patel, V.; Zhou, J; Jenkins, B.; Sievert, K. D. |
Article Title: |
Treatment satisfaction and goal attainment with onabotulinumtoxinA in patients with incontinence due to idiopathic OAB |
Abstract: |
INTRODUCTION AND HYPOTHESIS: Clinically meaningful overactive bladder syndrome (OAB) symptom relief is associated with patient satisfaction. This study evaluated the effects of onabotulinumtoxinA on patient satisfaction and goal attainment. METHODS: In a 36-week, multicenter, double-blind study, 313 participants with idiopathic OAB and urinary urgency incontinence inadequately managed with anticholinergics were randomized to placebo or one of five onabotulinumtoxinA doses. Assessment included a modified OAB-Patient Satisfaction with Treatment Questionnaire (PSTQ) and four Patient Global Assessment questions assessed changes in symptoms, quality of life, activity limitations, and emotions. RESULTS: Mean changes from baseline in OAB-PSTQ scores for the main module (Q2-Q13) at week 12 were greater for each onabotulinumtoxinA group (range, -31.5% to -48.9%) versus placebo (-17.6%). Greater proportions of patients in onabotulinumtoxinA groups attained their primary goal (range, 34.5% to 65.3%) versus placebo (23.7%). CONCLUSIONS: Patients with OAB are more likely to be satisfied and/or achieve their primary treatment goal with onabotulinumtoxinA treatment than with placebo, consistent with symptom improvements. |
Journal Title: |
International Urogynecology Journal
|
Volume: |
23 |
Issue: |
8 |
ISSN: |
0937-3462 |
Publisher: |
Unknown
|
Journal Place: |
England |
Date Published: |
2012 |
Start Page: |
1017 |
End Page: |
1025 |
Language: |
eng |
DOI/URL: |
|
Notes: |
JID: 101567041; 0 (onabotulinumtoxinA); EC 3.4.24.69 (Botulinum Toxins, Type A); 2011/09/28 [received]; 2011/12/24 [accepted]; 2012/01/25 [aheadofprint]; ppublish |