Role of image guided radiation therapy in obese patients with gynecologic malignancies Journal Article

Authors: Bray, T. S.; Kaczynski, A.; Albuquerque, K; Cozzi, F.; Roeske, J. C.
Article Title: Role of image guided radiation therapy in obese patients with gynecologic malignancies
Abstract: PURPOSE: We investigated the effect of body mass index on setup errors by analyzing daily shifts required in treating patients undergoing image guided radiation therapy (IGRT) for gynecologic malignancies. METHODS AND MATERIALS: Forty successive patients treated with daily kV-based IGRT for gynecologic malignancies between April 2009 and June 2012 were identified. Directional setup corrections were analyzed according to patient body mass index. Random and systematic setup errors were calculated. Image acquisition dose was estimated by performing ionization chamber measurements in a phantom. RESULTS: Obese patients had larger random setup errors, particularly in the right-left (R-L) direction, with a setup error of 7.6 mm, versus 3.9 mm for nonobese patients. The range of individual patient random errors in the R-L direction was 1.5 to 7.6 mm among nonobese patients versus 2.0 to 17.0 mm among obese patients (P = .03, F-test). For obese patients, daily IGRT prevented treating outside the planning target volume in 33% of fractions, versus 16% in the nonobese group (P = .001). The mean total image acquisition dose from daily kV-IGRT was approximately 3 cGy, versus 150 cGy if daily megavoltage portal imaging were used to correct for erratic setup errors. CONCLUSIONS: Daily kV-based IGRT in obese patients allows for correction of erratic setup error and minimizes excess dose from portal imaging.
Journal Title: Practical radiation oncology
Volume: 3
Issue: 4
ISSN: 1879-8500
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2013
Start Page: 249
End Page: 255
Language: eng
Notes: CI: Copyright (c) 2013; JID: 101558279; 2012/05/25 [received]; 2012/09/11 [revised]; 2012/09/13 [accepted]; 2012/10/22 [aheadofprint]; ppublish