Extensive sinovenous thrombosis and hemorrhagic infarction during therapy for T-cell acute lymphoblastic leukemia Journal Article

Local Library Link: Find It @ Loyola

Authors: Bhatia, R.; Rowley, H. D.; Mosher, J. C.; Alsheik, N. H.; Aagaard-Kienitz, B.; Diamond, C. D.; Iskandar, B. J.; Peters, A; Boriosi, J. P.; Patel, N. J.
Article Title: Extensive sinovenous thrombosis and hemorrhagic infarction during therapy for T-cell acute lymphoblastic leukemia
Abstract: Sinovenous thrombosis (SVT) is a well-recognized and serious complication in children treated for acute leukemia. This frequently occurs during or immediately upon completion of induction therapy and is commonly attributed to asparaginase therapy.Headache is the first and most common clinical symptom to occur during the early development of SVT. With advancement of the thrombosis, the clinical symptoms can progress to increased sleepiness, focal neurological deficit, seizures, and altered consciousness. We report the case of a 4-year-old girl who presented after several days of headaches and anorexia, which then progressed to seizures, left-sided weakness, and altered consciousness. She was later found to have a widespread and occlusive SVT with right cerebral hemorrhagic infarction. This case is notable for the extensive nature of the cerebral SVT and the child's complete clinical recovery from the neurological event. The report discusses the relation of the thrombosis and leukemia and also emphasizes the importance of early recognition and prompt management, while incorporating a collaborative multidisciplinary approach to prevent long-term consequences.
Journal Title: Pediatric emergency care
Volume: 29
Issue: 1
ISSN: 1535-1815; 0749-5161
Publisher: Unknown  
Journal Place: United States
Date Published: 2013
Start Page: 93
End Page: 97
Language: eng
DOI/URL:

10.1097/PEC.0b013e31827b5761

10.1097/PEC.0b013e31827b5761
Notes: ID: 13095; JID: 8507560; ppublish