Oral follicular lymphomas. A short report of 8 cases with assessment of the IGH/BCL2 gene fusion with fluorescence in situ hybridization Journal Article

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Authors: Argyris, P. P.; Dolan, M; Piperi, E.; Tosios, K. I.; Pambuccian, S. E.; Koutlas, I. G.
Article Title: Oral follicular lymphomas. A short report of 8 cases with assessment of the IGH/BCL2 gene fusion with fluorescence in situ hybridization
Abstract: OBJECTIVE: To present the clinicopathologic features and confirm the presence of the IGH/BCL2 gene fusion in an oral follicular lymphoma (OFL) series. STUDY DESIGN: Cases of OFLs were retrieved from a data base of non-Hodgkin lymphomas (NHL). Fluorescence in situ hybridization (FISH) was performed to confirm the IGH/BCL2 fusion. RESULTS: Eight (8.7%) of 92 NHL were OFLs. Six (75%) patients were male and two female (mean age: 73.4 +/- 14.8). The most frequent site was the palate. Five of the 8 patients are alive and without disease. Five (three grade 1 and two grade 2) of six successfully hybridized cases revealed the IGH/BCL2 gene fusion. The sixth case, a grade 3 follicular lymphoma (FL), demonstrated multiple BCL2 signals without IGH/BCL2 fusion. CONCLUSIONS: OFLs exhibit an indolent clinical behavior. In the present study, 5/6 cases in which FISH was successful had an IGH/BCL2 fusion as would result from the t(14; 18)(q32; q21) translocation commonly seen in FL of extraoral sites.
Journal Title: Oral surgery, oral medicine, oral pathology and oral radiology
Volume: 116
Issue: 3
ISSN: 2212-4411
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2013
Start Page: 343
End Page: 347
Language: eng
DOI/URL:

10.1016/j.oooo.2013.06.014

10.1016/j.oooo.2013.06.014
Notes: CI: Copyright (c) 2013; JID: 101576782; 2013/01/21 [received]; 2013/06/11 [revised]; 2013/06/14 [accepted]; ppublish