Characteristics of the microbiota in the urine of women with type 2 diabetes. Journal Article

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Authors: Penckofer, S; Limeira, R; Joyce, C; Grzesiak, M; Thomas-White, K; Wolfe, AJ
Article Title: Characteristics of the microbiota in the urine of women with type 2 diabetes.
Abstract: PURPOSE: The urinary microbiota in women with type 2 diabetes (T2DM) can have bacterial uropathogens which are more virulent. The primary objective was to describe and compare the characteristics of the microbiota in voided urine of women with and without T2DM. METHODS: Two cohorts of women: those with T2DM (n?=?87) and those without T2DM (n?=?49) were studied. Demographic data, hemoglobin A1c (HbA1c), fasting serum glucose, and voided urine were collected. To determine the characteristics of the microbiota in the urine, 16S rRNA gene sequencing was used. RESULTS: The genus Lactobacillus was more often present in women with T2DM (75.9%, n?=?66) than in the controls (59.2%, n?=?30) (p?=?0.042), as was the family Enterobacteriaceae (12.6% T2DM versus 2.0% control, p?=?0.055). There was evidence of an association between HbA1c and the relative abundance of the various bacteria in the total cohort. The relative abundance of Lactobacillus was positively associated (??=?0.19, 95% CI: 0.02, 0.34), while Corynebacterium (??=?-0.26, 95% CI: -0.41, -0.10) and Prevotella (??=?-0.23, 95% CI: -0.38, -0.06) were inversely associated with HbA1c. CONCLUSIONS: Enterobacteriaceae (e.g. E. coli) predispose women to urinary tract infections and since T2DM increases this risk, further study is needed. The species of Lactobacillus and its impact needs exploration.
Journal Title: Journal of diabetes and its complications
Publisher: Unknown  
Date Published: 2020