Letter to the Editor: Examining HBV RNA kinetics during NA treatment - are NA multifunctional antiviral agents? Journal Article

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Authors: Dahari, H; Vaillant, A; Cotler, SJ
Article Title: Letter to the Editor: Examining HBV RNA kinetics during NA treatment - are NA multifunctional antiviral agents?
Abstract: Carey et al recently proposed that HBV pregenomic RNA (pgRNA) is a sensitive indicator of covalently closed circular DNA (cccDNA) transcription status in patients receiving nucleos(t)ide analogue therapy (NA) for hepatitis B. pgRNA is transcribed from the cccDNA minichromosome and therefore reflects a product of cccDNA transcriptional activity and its prevalence within HBV-infected cells. They observed that some patients reached pgRNA negativity 12 months of NA, suggesting a surprisingly rapid decline in transcriptional activity/prevalence of cccDNA.
Journal Title: Hepatology (Baltimore, Md.)
ISSN: 1527-3350; 0270-9139
Publisher: American Association for the Study of Liver Diseases  
Date Published: 2020