Outcomes in Burn-Injured Patients Who Develop Sepsis. Journal Article


Authors: Rech, MA; Mosier, MJ; McConkey, K; Zelisko, S; Netzer, G; Kovacs, EJ; Afshar, M
Article Title: Outcomes in Burn-Injured Patients Who Develop Sepsis.
Abstract: OBJECTIVE: This study examines health outcomes in burn patients with sepsis. We hypothesized that burn patients with sepsis would have an increased odds risk for in-hospital death and longer intensive care unit (ICU) stays. METHODS: This was a retrospective cohort of consecutive patients admitted to the burn ICU with total burn surface area (TBSA) =10% and/or inhalation injury between January 2008 and March 2015. RESULTS: Overall 407 burn patients were included; the case-rate for sepsis was 39.1% (n=159); 20.1% (n=82) patients were septic and 18.9% (n=77) patients experienced septic shock . Patients with septic shock had the highest mortality rate (13.31% no sepsis vs. 3.7% sepsis vs. 49.4% septic shock, p 0.01). Median 28-day ICU-free days was higher in patients without sepsis (23 days [IQR 14 - 27] no sepsis vs. 0 days [IQR 0 - 10] sepsis vs. 0 days [IQR 0 - 0] septic shock, p 0.01). Sepsis (with or without shock) increased odds of in-hospital death (odds ratio [OR] 31.54, 95% confidence interval [CI] 1.02 - 1.29) in reference to the no sepsis group. With each incremental Sequential Organ Failure Assessment (SOFA) score or 10% TBSA increase, the odds risk for in-hospital death increased by 56% and 75%, respectively. CONCLUSION: Our study characterized outcomes in patients with sepsis after severe burn injury. The odds risk for in-hospital death was greater in patients with sepsis, increasing burn severity according to TBSA and SOFA score.
Journal Title: Journal of burn care research : official publication of the American Burn Association
ISSN: 1559-0488; 1559-047X
Publisher: Unknown  
Date Published: 2019