Association Between Diverticular Disease Requiring Surgical Intervention and Mortality in The Post-Lung Transplant Population - a retrospective cohort study. Journal Article


Authors: Tague, LK; Adams, W; Young, KA; Kwon, OJ; Mahoney, E; Lowery, EM
Article Title: Association Between Diverticular Disease Requiring Surgical Intervention and Mortality in The Post-Lung Transplant Population - a retrospective cohort study.
Abstract: BACKGROUND: Lung Transplant recipients are at increased risk of complicated diverticular disease. We aim to assess the rate of diverticular surgery in a post-lung transplantation population and identify risk factors for surgery. METHODS: We performed a retrospective cohort study of lung transplant recipients from 2007-2011. Demographic variables were evaluated with the Mann Whitney U and chi-squared tests. Cox regression was performed to evaluate 1- and 2-yr landmark survival, assess predictor variables of diverticular surgery and evaluate impact of surgery on CLAD development. RESULTS: 17 of 158 patients (10.7%) underwent diverticular-related surgery. Surgical patients had significantly worse survival than nonsurgical patients at 1yr [aHR 2.93 (1.05-8.21), p = 0.041] and 2yr [aHR 4.17 (1.26-13.84), p=0.020] landmark analyses. Transplant indication of alpha-1 antitrypsin disease and cystic fibrosis were significantly associated with the need for diverticular surgery. Emergent surgery was associated with poorer survival [aHR 5.12(1.00-26.27), p=0.050]. CONCLUSIONS: Lung transplant patients requiring surgery for complicated diverticular disease have significantly poorer survival than those who do not require surgery. Surgery was more common in patients transplanted for A1AT and CF. Optimal assessment and risk stratification of diverticular disease is necessary to prevent excessive morbidity and mortality following transplantation. This article is protected by copyright. All rights reserved.
Journal Title: Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277; 0934-0874
Publisher: European Society for Organ Transplantation  
Date Published: 2019
LUC Authors
  1. Erin Lowery
    15 Lowery
  2. Bill Adams
    35 Adams
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