Sinus tachycardia is associated with impaired exercise tolerance following heart transplantation. Journal Article


Authors: Peled, Y; Varnado, S; Lowes, BD; Zolty, R; Lyden, ER; Moulton, MJ; Um, JY; Raichlin, E
Article Title: Sinus tachycardia is associated with impaired exercise tolerance following heart transplantation.
Abstract: BACKGROUND: Sinus tachycardia often presents in heart transplantation (HTx) recipients, but data on its effect on exercise performance are limited. METHODS: Based on mean heart rate (HR) value 3 months after HTx, 181 patients transplanted from 2006 to 2015 at University of Nebraska Medical Center were divided into two groups: (i) HR95 beats/min (bpm, n=93); and (ii) HR=95 bpm (n=88). Cardiopulmonary exercise testing (CPET) was performed 1 year after HTx. RESULTS: Mean HR at 3 months post-HTx was 94±11 bpm and did not change significantly at 1 year post-HTx (96±11 bpm, P=.13). HR=95 bpm at 3 months was associated with younger donor age (OR 1.1; CI 1.0-1.1, P=.02), female donors (OR -2.4; CI 1.16-5.24 P=.02), and lack of donors' heavy alcohol use (OR -0.43; CI 0.17-0.61; P=.04). HR=95 bpm at 3 months post-HTx was independently associated with decreased exercise capacity in metabolic equivalent (P=.008), reduced peak VO (P=.006), and percent of predicted peak VO (P=.002) during CPET. CONCLUSIONS: HR=95 at 3 months following HTx is associated with reduced exercise tolerance in stable HTx recipients. Medical HR reduction after HTx could improve exercise performance after HTx and merits further investigation.
Journal Title: Clinical transplantation
ISSN: 1399-0012; 0902-0063
Publisher: Wiley Periodicals, Inc  
Date Published: 2017