Multisite study of the relationships between antemortem [C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Journal Article


Authors: Joie, R; Ayakta, N; Seeley, WW; Borys, E; Boxer, AL; DeCarli, C; Doré, V; Grinberg, LT; Huang, E; Hwang, JH; Ikonomovic, MD; Jack, C; Jagust, WJ; Jin, LW; Klunk, WE; Kofler, J; Lesman-Segev, OH; Lockhart, SN; Lowe, VJ; Masters, CL; Mathis, CA; McLean, CL; Miller, BL; Mungas, D; O'Neil, JP; Olichney, JM; Parisi, JE; Petersen, RC; Rosen, HJ; Rowe, CC; Spina, S; Vemuri, P; Villemagne, VL; Murray, ME; Rabinovici, GD
Article Title: Multisite study of the relationships between antemortem [C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.
Abstract: INTRODUCTION: We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [C]PIB-positron emission tomography ([C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aß-PET quantification. METHODS: Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings. RESULTS: CL values increased with each CERAD neuritic plaque score increment (median -3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aß phases (increases were detected starting at phase 2) with overlap between scores/phases. Findings were comparable across sites and when restricted to 56 patients who died within 2 years of PET. A threshold of 12.2 CL detected CERAD moderate-to-frequent neuritic plaques (area under the curve = 0.910, sensitivity = 89.2%, specificity = 86.4%), whereas 24.4 CL identified intermediate-to-high AD neuropathological changes (area under the curve = 0.894, sensitivity = 84.1%, specificity = 87.9%). DISCUSSION: Our study demonstrated the robustness of a multisite Centiloid [C]PIB-PET study and established a range of pathology-based CL thresholds.
Journal Title: Alzheimer's dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279; 1552-5260
Publisher: Elsevier Inc  
Date Published: 2018