Urine trouble: should we think differently about UTI? Journal Article

Authors: Price, T. K.; Hilt, E. E.; Dune, T. J.; Mueller, E. R.; Wolfe, A. J.; Brubaker, L
Article Title: Urine trouble: should we think differently about UTI?
Abstract: Urinary tract infection (UTI) is clinically important, given that it is one of the most common bacterial infections in adult women. However, the current understanding of UTI remains based on a now disproven concept that the urinary bladder is sterile. Thus, current standards for UTI diagnosis have significant limitations that may reduce the opportunity to improve patient care. Using data from our work and numerous other peer-reviewed studies, we identified four major limitations to the contemporary UTI description: the language of UTI, UTI diagnostic testing, the Escherichia coli-centric view of UTI, and the colony-forming units (CFU) threshold-based diagnosis. Contemporary methods and technology, combined with continued rigorous clinical research can be used to correct these limitations.
Keywords: Urinalysis; microbiome; urinary tract infection; Escherichia coli; Diagnostics; Pathogens
Journal Title: International Urogynecology Journal
Volume: 29
Issue: 2
ISSN: 0937-3462
Publisher: Unknown  
Journal Place: England
Date Published: 2018
Start Page: 205
End Page: 210
Language: eng
Notes: LR: 20180323; GR: 2U10 HD41250/NH/NIH HHS/United States; GR: U01 DK58229/NH/NIH HHS/United States; GR: R21 DK097435/NH/NIH HHS/United States; GR: R56 DK104718/NH/NIH HHS/United States; GR: P20 DK108268/NH/NIH HHS/United States; GR: R01 DK104718/NH/NIH HHS/United States; GR: RFC LU206998/Loyola University Chicago Stritch School of Medicine/International; GR: VESI-12D01/Astellas Pharma US/International; GR: MYRB-15A01/Astellas Pharma US/International; JID: 101567041; OTO: NOTNLM; 2017/09/11 00:00 [received]; 2017/11/27 00:00 [accepted]; 2017/12/28 06:00 [pubmed]; 2017/12/28 06:00 [medline]; 2017/12/28 06:00 [entrez]; ppublish