Biomarkers of Endothelial, Renal, and Platelet Dysfunction in Stage 5 Chronic Kidney Disease Hemodialysis Patients With Heart Failure Journal Article


Authors: McMillan, R.; Skiadopoulos, L.; Hoppensteadt, D; Guler, N.; Bansal, V.; Parasuraman, R.; Fareed, J
Article Title: Biomarkers of Endothelial, Renal, and Platelet Dysfunction in Stage 5 Chronic Kidney Disease Hemodialysis Patients With Heart Failure
Abstract: The aim of this study was to determine the role of endothelial, renal, and inflammatory biomarkers in the pathogenesis of heart failure (HF) in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD). Plasma levels of biomarkers-kidney injury molecule 1 (KIM-1), N-terminal pro brain natriuretic peptide (NT-proBNP), glycated hemoglobin, neutrophil gelatinase-associated lipocalin, interleukin-18,platelet-derived growth factor, platelet factor 4 (PF4), 25-OH vitamin D, parathyroid hormone (PTH), endothelin, and endocan-were measured in CKD5-HD patients at the Loyola University Ambulatory Dialysis facility. The HF (+) CKD5-HD patients, as compared to HF (-) CKD5-HD patients, exhibited significantly elevated NT-proBNP ( P = .0194) and KIM-1 ( P = .0485). The NT-proBNP in HF (+) CKD5-HD patients was found to correlate with the levels of serum potassium ( P = .023, R = -.39), calcium ( P = .029, R = -.38), and PF4 ( P = .045, R = -.35). The KIM-1 in HF (+) CKD5-HD patients was found to correlate with PTH ( P = .043, R = -.36) and 25-OH vitamin D ( P = .037, R = .36). Elevated plasma NT-proBNP and KIM-1 in CKD5-HD and HF (+) CKD5-HD patients suggest that natriuretic peptides and KIM-1 may contribute to the pathogenesis of HF in CKD5-HD patients.
Keywords: Hemodialysis; inflammatory biomarkers; HF; chronic kidney disease stage 5
Journal Title: Clinical Applied Thrombosis/Hemostasis
Volume: 24
Issue: 2
ISSN: 1938-2723
Publisher: Unknown  
Journal Place: United States
Date Published: 2018
Start Page: 235
End Page: 240
Language: eng
DOI/URL:
Notes: LR: 20180129; JID: 9508125; OTO: NOTNLM; 2017/10/11 06:00 [pubmed]; 2017/10/11 06:00 [medline]; 2017/10/10 06:00 [entrez]; ppublish
Related LUC Article