Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation Journal Article


Authors: Jabati, S.; Fareed, J; Liles, J.; Otto, A.; Hoppensteadt, D; Bontekoe, J.; Phan, T.; Walborn, A.; Syed, M.
Article Title: Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation
Abstract: The purpose of this study was to determine whether there are any differences in the levels of inflammatory, thrombotic, and collagen turnover biomarkers between individuals with atrial fibrillation (AF) and healthy volunteers. Circulating plasma levels of plasminogen activator inhibitor 1 (PAI-1), CD40-ligand (CD40-L), nucleosomes (which are indicators of cell death), C-reactive protein (CRP), procollagen III N-terminal propeptide (PIIINP), procollagen III C-terminal propeptide (PIIICP), procollagen I N-terminal propeptide, tissue plasminogen activator, and von Willebrand factor were analyzed as potential biomarkers of AF. Baseline plasma was collected from patients with AF prior to ablation surgery at Loyola University Medical Center. Individuals with AF had statistically significantly increased levels of PAI-1, CD40-L, and nucleosomes, when compared to the normal population ( P lt; .0001). Additionally, there was a statistically significant increase in the CRP ( P = .01), PIIINP ( P = .04), and PIIICP ( P = .0008) when compared to normal individuals. From this study, it is concluded that the prothrombotic, inflammatory, and collagen turnover biomarkers PAI-1, CD40-L, nucleosomes, CRP, PIIICP, and PIIINP are elevated in AF.
Keywords: Inflammation; Thrombosis; Atrial Fibrillation
Journal Title: Clinical Applied Thrombosis/Hemostasis
ISSN: 1938-2723
Publisher: Unknown  
Journal Place: United States
Date Published: 2018
Start Page: 1076029618761006
Language: eng
DOI/URL:
Notes: LR: 20180321; JID: 9508125; OTO: NOTNLM; 2018/03/22 06:00 [entrez]; 2018/03/22 06:00 [pubmed]; 2018/03/22 06:00 [medline]; aheadofprint; SO: Clin Appl Thromb Hemost. 2018 Jan 1:1076029618761006. doi: 10.1177/1076029618761006.