Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes Journal Article

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Authors: Frankel, J. H.; Boe, D. M.; Albright, J. M.; O'Halloran, E. B.; Carter, S. R.; Davis, C. S.; Ramirez, L; Burnham, E. L.; Gamelli, R. L.; Afshar, M; Kovacs, E. J.
Article Title: Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes
Abstract: This prospective study aimed to address changes in inflammatory response between different aged populations of patients who sustained burn and inhalation injury. Plasma and bronchoalveolar lavage (BAL) samples were collected from 104 patients within 15h of their estimated time of burn injury. Clinical variables, laboratory parameters, and immune mediator profiles were examined in association with clinical outcomes. Older patients were at higher odds for death after burn injury (odds ratio (OR)=7.37 per 10years, p=0.004). In plasma collected within 15h after burn injury, significant increases in the concentrations of interleukin 1 receptor antagonist (IL-1RA), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 6 (IL-6), granulocyte colony-stimulating factor (G-CSF), interferon-gamma-induced protein 10 (IP-10) and monocyte chemoattractant protein 1 (MCP-1) (p/=65 group. In the BAL fluid, MCP-1 was increased three-fold in the gt;/=65 group. This study suggests that changes in certain immune mediators were present in the older cohort, in association with in-hospital mortality.
Journal Title: Experimental gerontology
Volume: 105
ISSN: 1873-6815; 0531-5565
Publisher: Elsevier Inc  
Journal Place: England
Date Published: 2018
Start Page: 78
End Page: 86
Language: eng
DOI/URL:

S0531-5565(17)30693-9
Notes: LR: 20180329; CI: Copyright (c) 2017; GR: R01 AG018859/AG/NIA NIH HHS/United States; GR: R01 GM115257/GM/NIGMS NIH HHS/United States; GR: R24 AA019661/AA/NIAAA NIH HHS/United States; GR: K23 AA024503/AA/NIAAA NIH HHS/United States; GR: R21 AA023193/AA/NIAAA NIH HHS/United States; JID: 0047061; NIHMS918466; OTO: NOTNLM; PMCR: 2019/05/01 00:00; 2017/09/29 00:00 [received]; 2017/10/20 00:00 [revised]; 2017/10/23 00:00 [accepted]; 2019/05/01 00:00 [pmc-release]; 2017/10/31 06:00 [pubmed]; 2017/10/31 06:00 [medline]; 2017/10/30 06:00 [entrez]; ppublish