A computable phenotype for asthma case identification in adult and pediatric patients: External validation in the Chicago Area Patient-Outcomes Research Network (CAPriCORN) Journal Article

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Authors: Afshar, M; Press, V. G.; Robison, R. G.; Kho, A. N.; Bandi, S.; Biswas, A.; Avila, P. C.; Kumar, H. V. M.; Yu, B; Naureckas, E. T.; Nyenhuis, S. M.; Codispoti, C. D.
Article Title: A computable phenotype for asthma case identification in adult and pediatric patients: External validation in the Chicago Area Patient-Outcomes Research Network (CAPriCORN)
Abstract: OBJECTIVE: Comprehensive, rapid, and accurate identification of patients with asthma for clinical care and engagement in research efforts is needed. The original development and validation of a computable phenotype for asthma case identification occurred at a single institution in Chicago and demonstrated excellent test characteristics. However, its application in a diverse payer mix, across different health systems and multiple electronic health record vendors, and in both children and adults was not examined. The objective of this study is to externally validate the computable phenotype across diverse Chicago institutions to accurately identify pediatric and adult patients with asthma. METHODS: A cohort of 900 asthma and control patients was identified from the electronic health record between January 1, 2012 and November 30, 2014. Two physicians at each site independently reviewed the patient chart to annotate cases. RESULTS: The inter-observer reliability between the physician reviewers had a kappa-coefficient of 0.95 (95% CI 0.93-0.97). The accuracy, sensitivity, specificity, negative predictive value, and positive predictive value of the computable phenotype were all above 94% in the full cohort. CONCLUSIONS: The excellent positive and negative predictive values in this multi-center external validation study establish a useful tool to identify asthma cases in in the electronic health record for research and care. This computable phenotype could be used in large-scale comparative-effectiveness trials.
Journal Title: The Journal of asthma : official journal of the Association for the Care of Asthma
ISSN: 1532-4303; 0277-0903
Publisher: Unknown  
Journal Place: England
Date Published: 2017
Start Page: 1
End Page: 8
Language: eng
DOI/URL:

10.1080/02770903.2017.1389952
Notes: LR: 20171110; JID: 8106454; OTO: NOTNLM; 2017/10/14 06:00 [pubmed]; 2017/10/14 06:00 [medline]; 2017/10/14 06:00 [entrez]; aheadofprint; SO: J Asthma. 2017 Oct 13:1-8. doi: 10.1080/02770903.2017.1389952.