Severity of Inhalation Injury is Predictive of Alterations in Gas Exchange and Worsened Clinical Outcomes Journal Article


Authors: Sutton, T.; Lenk, I.; Conrad, P.; Halerz, M.; Mosier, M
Article Title: Severity of Inhalation Injury is Predictive of Alterations in Gas Exchange and Worsened Clinical Outcomes
Abstract: Inhalation injury (INH) is present in one third of large burn injuries and increases oxygenation and fluid resuscitation requirements, incidences of pulmonary complications, risk for multiple organ dysfunction syndrome (MODS), and overall mortality. Previous studies have demonstrated inconsistent correlation between bronchoscopic evaluation and clinical outcomes. The authors reviewed 161 patients admitted with a diagnosis of INH or underwent diagnostic bronchoscopy for suspected INH over a period of 8.5 years. One hundred one patients had concomitant burn injury and 60 had isolated INH. Seventeen patients had abbreviated injury score (AIS) 0, 81 patients had low-grade injury (AIS 1 and 2), and 63 patients had high-grade injury (AIS 3 and 4). Patients with high-grade INH had worse pulmonary dysfunction, worse oxygenation indices (P = 0.01) and plasma carboxyhemoglobin (COHgb; P lt; 0.01) on admission, increased fluid requirements (P lt; 0.01 at 24 hours; P = 0.04 at 48 hours), MODS (P = 0.04), pneumonia (P lt; 0.01), acute respiratory distress syndrome (P = 0.01 at 48 hours), fewer 28-day ventilator-free days (P lt; 0.01), greater ventilator dependence (P = 0.03), and longer length of stay (P lt; 0.01). Multivariate analyses demonstrated increased risk of MODS (P = 0.03), acute respiratory distress syndrome at 48 hours (P lt; 0.01), pneumonia (P = 0.01), prolonged ventilator dependence (P = 0.03), and a trend toward mortality (P = 0.08) with higher AIS groups. More severe INH correlates with early oxygenation impairments and is associated with more complicated hospitalization, fluid resuscitation requirements, and ventilation demands. Severe INH is associated with and predictive of increased morbidity and mortality.
Keywords: Surgery
Journal Title: Journal of burn care research : official publication of the American Burn Association
ISSN: 1559-0488; 1559-047X
Publisher: Unknown  
Journal Place: United States
Date Published: 2017
Language: eng
DOI/URL:
Notes: LR: 20170601; JID: 101262774; aheadofprint