Resveratrol and calcium signaling: molecular mechanisms and clinical relevance Journal Article


Authors: McCalley, A. E.; Kaja, S.; Payne, A. J.; Koulen, P.
Article Title: Resveratrol and calcium signaling: molecular mechanisms and clinical relevance
Abstract: Resveratrol is a naturally occurring compound contributing to cellular defense mechanisms in plants. Its use as a nutritional component and/or supplement in a number of diseases, disorders, and syndromes such as chronic diseases of the central nervous system, cancer, inflammatory diseases, diabetes, and cardiovascular diseases has prompted great interest in the underlying molecular mechanisms of action. The present review focuses on resveratrol, specifically its isomer trans-resveratrol, and its effects on intracellular calcium signaling mechanisms. As resveratrol's mechanisms of action are likely pleiotropic, its effects and interactions with key signaling proteins controlling cellular calcium homeostasis are reviewed and discussed. The clinical relevance of resveratrol's actions on excitable cells, transformed or cancer cells, immune cells and retinal pigment epithelial cells are contrasted with a review of the molecular mechanisms affecting calcium signaling proteins on the plasma membrane, cytoplasm, endoplasmic reticulum, and mitochondria. The present review emphasizes the correlation between molecular mechanisms of action that have recently been identified for resveratrol and their clinical implications.
Journal Title: Molecules (Basel, Switzerland)
Volume: 19
Issue: 6
ISSN: 1420-3049; 1420-3049
Publisher: Unknown  
Journal Place: Switzerland
Date Published: 2014
Start Page: 7327
End Page: 7340
Language: ENG
DOI/URL:
Notes: LR: 20161019; GR: P01 AG022550/AG/NIA NIH HHS/United States; GR: P01 AG027956/AG/NIA NIH HHS/United States; GR: AG010485/AG/NIA NIH HHS/United States; GR: R01 EY014227/EY/NEI NIH HHS/United States; GR: AG022550/AG/NIA NIH HHS/United States; GR: P01 AG010485/AG/NIA NIH HHS/United States; GR: EY014227/EY/NEI NIH HHS/United States; GR: R01 EY022774/EY/NEI NIH HHS/United States; GR: EY022774/EY/NEI NIH HHS/United States; GR: AG027956/AG/NIA NIH HHS/United States; GR: S10 RR027093/RR/NCRR NIH HHS/United States; GR: RR027093/RR/NCRR NIH HHS/United States; JID: 100964009; 0 (Stilbenes); Q369O8926L (resveratrol); NIHMS623718; OID: NLM: NIHMS623718; OID: NLM: PMC4160047; 2014/04/16 [received]; 2014/05/23 [revised]; 2014/05/23 [accepted]; epublish