Investigation of iterative image reconstruction in low-dose breast CT Journal Article


Authors: Bian, J.; Yang, K.; Boone, J. M.; Han, X; Sidky, E. Y.; Pan, X.
Article Title: Investigation of iterative image reconstruction in low-dose breast CT
Abstract: There is interest in developing computed tomography (CT) dedicated to breast-cancer imaging. Because breast tissues are radiation-sensitive, the total radiation exposure in a breast-CT scan is kept low, often comparable to a typical two-view mammography exam, thus resulting in a challenging low-dose-data-reconstruction problem. In recent years, evidence has been found that suggests that iterative reconstruction may yield images of improved quality from low-dose data. In this work, based upon the constrained image total-variation minimization program and its numerical solver, i.e., the adaptive steepest descent-projection onto the convex set (ASD-POCS), we investigate and evaluate iterative image reconstructions from low-dose breast-CT data of patients, with a focus on identifying and determining key reconstruction parameters, devising surrogate utility metrics for characterizing reconstruction quality, and tailoring the program and ASD-POCS to the specific reconstruction task under consideration. The ASD-POCS reconstructions appear to outperform the corresponding clinical FDK reconstructions, in terms of subjective visualization and surrogate utility metrics.
Journal Title: Physics in Medicine and Biology
Volume: 59
Issue: 11
ISSN: 1361-6560; 0031-9155
Publisher: Unknown  
Journal Place: England
Date Published: 2014
Start Page: 2659
End Page: 2685
Language: eng
DOI/URL:
Notes: LR: 20160303; GR: R01 CA120540/CA/NCI NIH HHS/United States; GR: R01 CA120540/CA/NCI NIH HHS/United States; GR: R01 CA158446/CA/NCI NIH HHS/United States; GR: R01 CA158446/CA/NCI NIH HHS/United States; GR: R01 CA165221/CA/NCI NIH HHS/United States; GR: R01 EB000225/EB/NIBIB NIH HHS/United States; GR: R01 EB000225/EB/NIBIB NIH HHS/United States; GR: R01 EB002138/EB/NIBIB NIH HHS/United States; GR: R01 EB002138/EB/NIBIB NIH HHS/United States; GR: T32 EB013180/EB/NIBIB NIH HHS/United States; JID: 0401220; NIHMS593123; OID: NLM: NIHMS593123; OID: NLM: PMC4104195; 2014/05/01 [aheadofprint]; ppublish