Prolonged ovarian hormone deprivation alters the effects of 17beta-estradiol on microRNA expression in the aged female rat hypothalamus Journal Article

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Authors: Rao, Y. S.; Shults, C. L.; Pinceti, E.; Pak, T. R.
Article Title: Prolonged ovarian hormone deprivation alters the effects of 17beta-estradiol on microRNA expression in the aged female rat hypothalamus
Abstract: Administration of 17beta-estradiol (E2) has beneficial effects on cognitive function in peri- but not post-menopausal women, yet the molecular mechanisms underlying age-related changes in E2 action remain unclear. We propose that there is a biological switch in E2 action that occurs coincident with age and length of time after ovarian hormone depletion, and we hypothesized that age-dependent regulation of microRNAs (miRNAs) could be the molecular basis for that switch. Previously we showed that miRNAs are regulated by E2 in young compared to aged female rats. Here we tested whether increasing lengths of ovarian hormone deprivation in aged females altered E2 regulation of these mature miRNAs. In addition, we determined where along the miRNA biogenesis pathway E2 exerted its effects. Our results showed that age and increased lengths of ovarian hormone deprivation abolished the ability of E2 to regulate mature miRNA expression in the brain. Further, we show that E2 acted at specific points along the miRNA biogenesis pathway.
Journal Title: Oncotarget
ISSN: 1949-2553; 1949-2553
Publisher: Unknown  
Date Published: 2015
Language: ENG
DOI/URL:

10.18632/oncotarget.5433
Notes: LR: 20151016; JID: 101532965; OTO: NOTNLM; 2015/08/17 [received]; 2015/09/29 [accepted]; aheadofprint