A central role for inducible heat-shock protein 70 in autoimmune vitiligo Journal Article

Authors: Mosenson, J. A.; Eby, J. M.; Hernandez, C.; Le Poole, I. C.
Article Title: A central role for inducible heat-shock protein 70 in autoimmune vitiligo
Abstract: Inducible heat-shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells (DCs) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress, melanocytes will secrete antigen-bound HSP70i to act as an alarm signal in activating DCs that comes equipped with an address of origin to drive the autoimmune response in vitiligo. Here we pose that if the autoimmune response is funnelled through HSP70i, then blocking the stress protein from activating DCs can lend new treatment opportunities for vitiligo.
Keywords: Humans; Melanoma/immunology; Autoimmune; Stress; T cell; mouse model; Autoimmune Diseases/etiology/immunology/therapy; Cancer Vaccines/therapeutic use; HSP70 Heat-Shock Proteins/immunology/metabolism; Melanocytes/immunology; Proteins/metabolism; Vitiligo/etiology/immunology/therapy; dendritic cell; depigmentation; heat-shock protein
Journal Title: Experimental dermatology
Volume: 22
Issue: 9
ISSN: 1600-0625; 0906-6705
Publisher: Wiley Periodicals, Inc  
Journal Place: Denmark
Date Published: 2013
Start Page: 566
End Page: 569
Language: eng
Notes: LR: 20141113; CI: (c) 2013; GR: R01 AR054749/AR/NIAMS NIH HHS/United States; GR: R01 AR54749/AR/NIAMS NIH HHS/United States; JID: 9301549; 0 (Cancer Vaccines); 0 (HSP70 Heat-Shock Proteins); 0 (Proteins); 0 (lysosomal proteins); CIN: Exp Dermatol. 2013 Sep;22(9):570-1. PMID: 23947669; NIHMS488978; OID: NLM: NIHMS488978; OID: NLM: PMC3745819; OTO: NOTNLM; 2013/05/28 [accepted]; 2013/06/20 [aheadofprint]; ppublish