Influence of perinatal factors in short- and long-term outcomes of infants born at 23 weeks of gestation Journal Article


Authors: Miltaha, H. R.; Fahey, L. M.; Sajous, C. H.; Morrison, J. C.; Muraskas, J. K.
Article Title: Influence of perinatal factors in short- and long-term outcomes of infants born at 23 weeks of gestation
Abstract: OBJECTIVE: Investigate the influence of perinatal factors on short- and long-term outcomes for infants born at 23 weeks of gestation. STUDY DESIGN: This is a retrospective study over a 25-year period (1987-2011) of 87 successfully resuscitated infants at 23 weeks of gestation. We investigated the effects of poor prenatal care, race, gender, chorioamnionitis, antenatal corticosteroids, delivery route/location, low 5-minute Apgar score, birth weight, and multiple births on short- and long-term outcomes. RESULTS: The mortality rate was 43% (37/87). A total of 88% (44/50) of the survivors were followed at 2 years corrected age with 66% (29/44) diagnosed with a moderate-to-severe neurological impairment. Outborn and multiple birth infants had significantly higher mortality (p-value 0.042 and 0.006, respectively). Lack of exposure to antenatal steroids and lower birth weight significantly increased the disability score (p-value 0.042 and 0.003, respectively). CONCLUSION: Multiple perinatal factors significantly influence outcomes at the threshold of viability.
Journal Title: American Journal of Perinatology
Volume: 32
Issue: 7
ISSN: 1098-8785; 0735-1631
Publisher: USA  
Journal Place: United States
Date Published: 2015
Start Page: 627
End Page: 632
Language: eng
DOI/URL:
Notes: CI: Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001; JID: 8405212; 2014/12/08 [epublish]; 2014/12/08 [aheadofprint]; ppublish