The cancer COMPASS: navigating the functions of MLL complexes in cancer Journal Article

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Authors: Ford, D. J.; Dingwall, A. K.
Article Title: The cancer COMPASS: navigating the functions of MLL complexes in cancer
Abstract: The mixed-lineage leukemia family of histone methyltransferases (MLL1-4, or KMT2A-D) were previously linked to cancer through the founding member, MLL1/KMT2A, which is often involved in translocation-associated gene fusion events in childhood leukemias. However, in recent years, a multitude of tumor exome sequencing studies have revealed that orthologues MLL3/KMT2C and MLL2/KMT2D are mutated in a significant percentage of a large variety of malignancies, particularly solid tumors. These unexpected findings necessitate a deeper inspection into the activities and functional differences between the MLL/KMT2 family members. This review provides an overview of this protein family and its relation to cancers, focusing on the recent links between MLL3/KMT2C and MLL2/4/KMT2D and their potential roles as tumor suppressors in an assortment of cell types.
Journal Title: Cancer genetics
Volume: 208
Issue: 5
ISSN: 2210-7762
Publisher: Elsevier Inc  
Date Published: 2015
Start Page: 178
End Page: 191
Language: ENG
DOI/URL:

S2210-7762(15)00006-X
Notes: LR: 20150322; CI: Copyright (c) 2015; JID: 101539150; OTO: NOTNLM; 2014/10/31 [received]; 2015/01/20 [revised]; 2015/01/21 [accepted]; aheadofprint