Age- and gender-related changes in ventricular performance in wild-type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging: a retrospective study Journal Article

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Authors: Koch, S. E.; Haworth, K. J.; Robbins, N.; Smith, M. A.; Lather, N.; Anjak, A.; Jiang, M.; Varma, P.; Jones, W. K.; Rubinstein, J.
Article Title: Age- and gender-related changes in ventricular performance in wild-type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging: a retrospective study
Abstract: Detailed studies in animal models to assess the importance of aging animals in cardiovascular research are rather scarce. The increase in mouse models used to study cardiovascular disease makes the establishment of physiologic aging parameters in myocardial function in both male and female mice critical. Forty-four FVB/N mice were studied at multiple time points between the ages of 3 and 16 mo using high-frequency echocardiography. Our study found that there is an age-dependent decrease in several systolic and diastolic function parameters in male mice, but not in female mice. This study establishes the physiologic age- and gender-related changes in myocardial function that occur in mice and can be measured with echocardiography. We report baseline values for traditional echocardiography and advanced echocardiographic techniques to measure discrete changes in cardiac function in the commonly employed FVB/N strain.
Journal Title: Ultrasound in medicine biology
Volume: 39
Issue: 11
ISSN: 1879-291X; 0301-5629
Publisher: Elsevier Inc  
Journal Place: England
Date Published: 2013
Start Page: 2034
End Page: 2043
Language: eng
DOI/URL:

10.1016/j.ultrasmedbio.2013.04.002
Notes: CI: Copyright (c) 2013; GR: HL091478/HL/NHLBI NIH HHS/United States; GR: R01 HL091478/HL/NHLBI NIH HHS/United States; JID: 0410553; OTO: NOTNLM; 2012/10/13 [received]; 2013/03/28 [revised]; 2013/04/04 [accepted]; 2013/06/19 [aheadofprint]; ppublish