Physical activity and mammographic breast density: a systematic review Journal Article


Authors: Yaghjyan, L.; Colditz, G. A.; Wolin, K. Y.
Article Title: Physical activity and mammographic breast density: a systematic review
Abstract: Studies show a protective relationship between physical activity and breast cancer risk across the life course from menarche to postmenopausal years. Mammographic breast density is a known and strong breast cancer risk factor. Whether the association of physical activity with breast cancer risk is mediated through mammographic breast density is poorly understood. This systematic review summarizes published studies that investigated the association between physical activity and mammographic breast density and discusses the methodological issues that need to be addressed. We included in this review studies that were published before October 31, 2011 that were accessible in full-text format and were published in English. We identified 20 studies through the PubMed Central, BioMed Central, Embase, and Scopus and using the search terms "physical activity and breast density" and "exercise and breast density" as well as through manual searches of the bibliographies of the articles identified in electronic searches. We found no evidence of association between physical activity and breast density across the studies by grouping them first by the timing of physical activity assessment (in adolescence, current/recent, past, and lifetime) and then by women's menopausal status (premenopausal and postmenopausal). Given the strength of the relationship between physical activity and breast cancer and the null findings of this review, it is unlikely that the effect of physical activity is mediated through an effect on breast density.
Journal Title: Breast cancer research and treatment
Volume: 135
Issue: 2
ISSN: 1573-7217; 0167-6806
Publisher: Unknown  
Journal Place: Netherlands
Date Published: 2012
Start Page: 367
End Page: 380
Language: eng
DOI/URL:
Notes: LR: 20130708; GR: R01 CA148791/CA/NCI NIH HHS/United States; GR: R01CA 148791/CA/NCI NIH HHS/United States; GR: U54 CA155496/CA/NCI NIH HHS/United States; GR: U54 CA155496/CA/NCI NIH HHS/United States; JID: 8111104; NIHMS457914; OID: NLM: NIHMS457914; OID: NLM: PMC3641148; 2012/04/24 [received]; 2012/06/25 [accepted]; 2012/07/20 [aheadofprint]; ppublish