Decreased survival in necrotizing enterocolitis is significantly associated with neonatal and maternal blood group: the AB isoagglutinin hypothesis Journal Article

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Authors: Thomson, T.; Habeeb, O; DeChristopher, P. J.; Glynn, L.; Yong, S.; Muraskas, J
Article Title: Decreased survival in necrotizing enterocolitis is significantly associated with neonatal and maternal blood group: the AB isoagglutinin hypothesis
Abstract: Objective:To determine the effect of neonatal and maternal blood group on the mortality risk from necrotizing enterocolitis (NEC).Study Design:Retrospective chart review of all neonates admitted to the neonatal intensive care unit over 24 years. Data on birth date, gestational age, maternal/neonatal blood group, number of transfusions, and survival time (defined as date of birth to date of death/discharge) were collected on those with NEC.Result:276 neonates with Bell stage II-III NEC were analyzed. AB neonates had a significantly higher risk of mortality from NEC compared with other blood groups (HR 2.87; 95% CI 1.40 to 5.89; P=0.003). Multivariate analysis showed AB blood group to be an independent risk factor for mortality from NEC.Conclusion:Neonatal and maternal blood groups are significantly associated with a neonate's survival from NEC. The increased mortality of AB neonates may be related to factors such as neonatal blood group antigens and/or transplacental transfer of isoagglutinins.
Journal Title: Journal of Perinatology
Volume: 32
Issue: 8
ISSN: 0743-8346
Publisher: Unknown  
Date Published: 2012
Start Page: 626
End Page: 630
Language: English
DOI/URL:

http://search.ebscohost.com.archer.luhs.org/login.aspx?direct=true=rzh=2011626867=ehost-live

http://search.ebscohost.com.archer.luhs.org/login.aspx?direct=true=rzh=2011626867=ehost-live

10.1038/jp.2011.150
Notes: ID: 12495; JS: Biomedical; JS: Peer Reviewed; JS: USA; EM: 20120810