The functional role of notch signaling in triple-negative breast cancer Journal Article

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Authors: Speiser, J. J.; Ersahin, C.; Osipo, C
Article Title: The functional role of notch signaling in triple-negative breast cancer
Abstract: The term "triple-negative breast cancer" (TNBC) is a heterogeneous subtype of breast cancer. Unfortunately, due to the lack of expression of hormone receptors and human epidermal growth factor receptor-2, therefore the lack of US Food and Drug Administration-approved targeted therapies, TNBC has the worst prognosis of all subtypes of breast cancer. Notch signaling has emerged as a pro-oncogene in several human malignancies and has particularly been associated with the triple-negative subtype of breast cancer. This chapter explores the role of Notch signaling in triple negative and other subtypes of breast cancer, the relationship of Notch with other breast cancer biomarkers, prognostic indicators associated with Notch, and potential therapeutic strategies targeting Notch inhibition. Hopefully, better understanding of this signaling pathway in the future will lead to optimal molecular therapeutic treatments for TNBC patients, improving their quality of life and outcome.
Journal Title: Vitamins and hormones
Volume: 93
ISSN: 0083-6729; 0083-6729
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2013
Start Page: 277
End Page: 306
Language: eng
DOI/URL:

10.1016/B978-0-12-416673-8.00013-7

10.1016/B978-0-12-416673-8.00013-7
Notes: CI: Copyright (c) 2013; JID: 0413601; ppublish