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Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization. Journal Article
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| Authors: | Siddiqui, F; O'Connor, J. R.; Nagaro, K.; Cheknis, A; Sambol, S. P.; Vedantam, G.; Gerding, D. N.; Johnson, S |
| Article Title: | Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization. |
| Abstract: | Toxin A has historically been regarded as the primary virulence determinant in Clostridium difficile infection, but naturally occurring toxin A-negative, toxin B-positive (A-/B+) C. difficile strains are known to be virulent. To determine the role of toxin B in these strains, we immunized hamsters with a toxoid prepared from purified toxin B to determine whether they would be protected from lethal challenge with an A-/B+ strain of C. difficile. |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 205 |
| Issue: | 1 |
| ISSN: | 1537-6613 |
| Publisher: | Unknown |
| Journal Place: | United States |
| Date Published: | 2012 |
| Start Page: | 128 |
| End Page: | 133 |
| Language: | English |
| DOI/URL: | |
| Notes: | ID: 12106; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: ih3, 0413675; CAS Registry/EC Number/Name of Substance: 0 (Bacterial Proteins). 0 (Bacterial Toxins). 0 (Enterotoxins). 0 (Toxoids). 0 (Virulence Factors). 0 (tcdA protein, Clostridium difficile). 0 (toxB protein, Clostridium difficile).; Electronic Date of Publication: 20111128; Entry Date: 20120214 |
