Complete pathologic response to neoadjuvant radiotherapy is predictive of oncological outcome in patients with soft tissue sarcoma Journal Article

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Authors: Shah, D; Borys, D; Martinez, S. R.; Li, C. S.; Tamurian, R. M.; Bold, R. J.; Monjazeb, A.; Canter, R. J.
Article Title: Complete pathologic response to neoadjuvant radiotherapy is predictive of oncological outcome in patients with soft tissue sarcoma
Abstract: We sought to determine if complete pathological necrosis (pathCR) predicts favorable oncological outcome in soft tissue sarcoma (STS) patients receiving pre-operative radiation monotherapy (RT). PATIENTS AND METHODS: We evaluated 30 patients with primary STS treated with neoadjuvant RT followed by definitive resection, from 2000 to 2010 at our institution. We defined >/= 95% tumor necrosis as pathCR. RESULTS: There were 22 STS of the extremities (73%), 7 of the retroperitoneum (23%), and 1 (4%) of the trunk. The median pathological percentage of tumor necrosis was 35% (range 5-100%) with three tumors (10%) demonstrating pathCR. With a median follow-up of 40 months, the 5-year local recurrence-free survival (LRFS), distant recurrence-free survival (DRFS), and overall survival (OS) for the entire cohort were 100%, 61% +/- 11%, and 69% +/- 11%, respectively. Among patients with pathCR, 3-year DRFS was 100% compared to 63+/-11% in patients without pathCR (p=0.28). CONCLUSION: Following neoadjuvant RT for STS, pathCR is associated with a clinically but not statistically significant 37% improvement in 3-year DRFS.
Journal Title: Anticancer Research
Volume: 32
Issue: 9
ISSN: 1791-7530; 0250-7005
Publisher: Unknown  
Journal Place: Greece
Date Published: 2012
Start Page: 3911
End Page: 3915
Language: eng
Notes: GR: UL1 RR024146/RR/NCRR NIH HHS/United States; JID: 8102988; ppublish