Silymarin for HCV infection Journal Article


Authors: Polyak, S. J.; Oberlies, N. H.; Pecheur, E. I.; Dahari, H; Ferenci, P; Pawlotsky, J. M.
Article Title: Silymarin for HCV infection
Abstract: Silymarin, an extract of milk thistle seeds, and silymarin-derived compounds have been considered hepatoprotective since the plant was first described in ancient times. Hepatoprotection is defined as several non-mutually exclusive biological activities including antiviral, antioxidant, anti-inflammatory and immunomodulatory functions. Despite clear evidence for silymarin-induced hepatoprotection in cell culture and animal models, evidence for beneficial effects in humans has been equivocal. This review will summarize the current state of knowledge on silymarin in the context of HCV infection. The information was collated from a recent workshop on silibinin in Germany.
Keywords: Hepatology
Journal Title: Antiviral Therapy
Volume: 18
Issue: 2
ISSN: 2040-2058; 1359-6535
Publisher: Unknown  
Journal Place: England
Date Published: 2013
Start Page: 141
End Page: 147
Language: eng
DOI/URL:
Notes: GR: P20-GM103452/GM/NIGMS NIH HHS/United States; GR: R01 AI078881/AI/NIAID NIH HHS/United States; GR: R01 AT006842/AT/NCCAM NIH HHS/United States; GR: R01AT006842/AT/NCCAM NIH HHS/United States; GR: R56/R01-AI078881/AI/NIAID NIH HHS/United States; JID: 9815705; 2012/07/11 [accepted]; 2012/09/25 [aheadofprint]; ppublish