Eosinophilic cytoplasmic inclusion bodies in vesicular multinucleated melanocytes: a clue to the diagnosis of benign melanocytic lesions Journal Article


Authors: Patino, W. D.; Hutchens, K. A.; Kapil, J.; Chiou, Y.; Gottlieb, G. J.
Article Title: Eosinophilic cytoplasmic inclusion bodies in vesicular multinucleated melanocytes: a clue to the diagnosis of benign melanocytic lesions
Abstract: Different types of multinucleated melanocytes have been described in benign and malignant melanocytic lesions. Here we describe a relatively common, though underappreciated, type of multinucleated melanocyte characterized by abundant vesicular and fibrillary-appearing cytoplasm containing one or multiple eosinophilic inclusion bodies. In our experience, these vesicular multinucleated melanocytes with inclusion bodies are invariably seen in nevi of long duration. The presence of these cells can be a reassuring histological finding when evaluating a melanocytic lesion.
Keywords: Adult; Female; Humans; Pathology; Adolescent; Predictive Value of Tests; Biopsy; Cell Nucleus/pathology; Skin Neoplasms/pathology; Cytoplasmic Vesicles/pathology; Eosinophils/pathology; Inclusion Bodies/pathology; Melanocytes/pathology; Nevus, Pigmented/pathology
Journal Title: The American Journal of Dermatopathology
Volume: 34
Issue: 4
ISSN: 1533-0311; 0193-1091
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: 424
End Page: 427
Language: eng
DOI/URL:
Notes: JID: 7911005; ppublish