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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry Journal Article
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| Authors: | Monda, K. L.; Tayo, B. O.; Cooper, R. S.; et.al. |
| Article Title: | A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry |
| Abstract: | Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 x 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 x 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 x 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 x 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations. |
| Journal Title: | Nature genetics |
| Volume: | 45 |
| Issue: | 6 |
| ISSN: | 1546-1718; 1061-4036 |
| Publisher: | Unknown |
| Journal Place: | United States |
| Date Published: | 2013 |
| Start Page: | 690 |
| End Page: | 696 |
| Language: | eng |
| DOI/URL: | |
| Notes: | GR: R01 CA056678/CA/NCI NIH HHS/United States; GR: R01 CA082664/CA/NCI NIH HHS/United States; GR: R01 CA092579/CA/NCI NIH HHS/United States; GR: R01 CA100374/CA/NCI NIH HHS/United States; GR: R01 CA141712/CA/NCI NIH HHS/United States; GR: R01 LM010098/LM/NLM NIH HHS/United States; GR: U01 HL054471/HL/NHLBI NIH HHS/United States; JID: 9216904; 2012/09/05 [received]; 2013/03/18 [accepted]; 2013/04/14 [aheadofprint]; ppublish |
