The cell biology of TRIM5alpha Journal Article

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Authors: Lukic, Z.; Campbell, E. M.
Article Title: The cell biology of TRIM5alpha
Abstract: The tripartite motif (TRIM)-containing proteins are involved in many cellular functions such as cell signaling, apoptosis, cell differentiation, and immune modulation. TRIM5 proteins, including TRIM5alpha and TRIM-Cyp, are known to possess antiretroviral activity against many different retroviruses. Besides being retroviral restriction factors, TRIM5 proteins participate in other cellular functions that have recently emerged in the study of TRIM5alpha. In this review, we discuss properties of TRIM5alpha such as cytoplasmic body formation, protein turnover, and trafficking. Also, we discuss recent insights into innate immune modulation mediated by TRIM5alpha, highlighting the various functions TRIM5alpha has in cellular processes.
Journal Title: Current HIV/AIDS Reports
Volume: 9
Issue: 1
ISSN: 1548-3576
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: 73
End Page: 80
Language: English
DOI/URL:

http://ovidsp.ovid.com/ovidweb.cgi?T=JS=Y=N=fulltext=medl=22193888
Notes: ID: 12118; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; [Review]; Publishing Model: Journal available in: Print Citation processed from: Internet; NLM Journal Code: 101235661; CAS Registry/EC Number/Name of Substance: 0 (Carrier Proteins). 0 (TRIM5 protein, human). 0 (Transcription Factors).; Entry Date: 20120328