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Low vitamin D levels are associated with increased rejection and infections after lung transplantation. Journal Article
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| Authors: | Lowery, E. M.; Bemiss, B.; Cascino, T.; Durazo-Arvizu, R. A.; Forsythe, S. M.; Alex, C.; Laghi, F.; Love, R. B.; Camacho, P |
| Article Title: | Low vitamin D levels are associated with increased rejection and infections after lung transplantation. |
| Abstract: | BACKGROUND: The prevalence of vitamin D deficiency in lung disease is greater than in the general population. Vitamin D deficiency may negatively affect immune and lung function. Accordingly, we hypothesized that lung transplant recipients with vitamin D deficiency are more susceptible to rejection and infections after transplantation. METHODS: Transplant outcomes were reviewed in a retrospective cohort of 102 lung transplant recipients who had 25-hydroxyvitamin D [25(OH)D] levels drawn during the near-transplant period (100 days pre- or post-transplant). RESULTS: In the near-transplant period, 80% of recipients were 25(OH)D-deficient and 20% were not 25(OH)D-deficient. Episodes of acute cellular rejection in the deficient group were more frequent than in the non-deficient group [mean 1.27 (0.99 to 1.55) vs 0.52 (0.12 to 0.93), p = 0.006]. The rejection rate in the deficient group was more than double that of the the non-deficient group [IRR 2.43 (1.30 to 4.52), p = 0.005]. Infectious episodes were also more frequent in the deficient group than in the non-deficient group [mean 4.01 (3.24 to 4.79) vs 2.71 (1.47 to 3.96), p = 0.04]. The mortality rate of recipients who remained 25(OH)D-deficient 1 year after transplant was almost 5-fold higher than in recipients who were not 25(OH)D-deficient [IRR 4.79 (1.06 to 21.63), p = 0.04]. CONCLUSIONS: Low serum 25(OH)D levels in lung transplant recipients were associated with increased incidence of acute rejection and infection. The mortality of recipients who remained deficient 1 year post-transplant was higher than that of recipients who maintained normal vitamin D levels at 1 year post-transplant. Copyright 2012 International Society for Heart and Lung Transplantation. All rights reserved. |
| Journal Title: | Journal of Heart Lung Transplantation |
| Volume: | 31 |
| Issue: | 7 |
| ISSN: | 1053-2498 |
| Publisher: | Unknown |
| Journal Place: | United States |
| Date Published: | 2012 |
| Start Page: | 700 |
| End Page: | 707 |
| Language: | English |
| DOI/URL: |
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| Notes: | ID: 12625; Status: MEDLINE; Comments: Comment in: J Heart Lung Transplant. 2012 Jul;31(7):789-90; PMID: 22595753; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: a0q, 9102703 |
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