Reliability and responsiveness of the Urgency Severity and Life Impact Questionnaire (USIQ) Journal Article


Authors: Lowenstein, L.; Rickey, L.; Kenton, K.; FitzGerald, M. P.; Brubaker, L; Tulke, M.; Fordham, J.; Mueller, E. R.
Article Title: Reliability and responsiveness of the Urgency Severity and Life Impact Questionnaire (USIQ)
Abstract: INTRODUCTION AND HYPOTHESIS: The aims of this study are (1) to assess the reliability (test-retest) of the Urgency Severity and Life Impact Questionnaire (USIQ) and (2) to test the effect of extended-release tolterodine on symptoms of urinary urgency using this validated instrument. METHODS: To measure reliability, women with overactive bladder (OAB) completed the USIQ on two separate occasions, prior to treatment for OAB. To assess the responsiveness, the USIQ participants completed the above-mentioned questionnaires prior to and following 4 weeks of treatment for OAB with extended-release tolterodine. RESULTS: USIQ-S and USIQ-QoL scores at the two visits did not differ significantly. Repeated measures of USIQ-S and USIQ-QoL demonstrated a moderate to excellent intraclass correlation coefficient (0.64-0.74; P 0.0001 and 0.48-0.91, P 0.0001, respectively). A significant decrease in mean USIQ-S and USIQ-QOL (71 +/- 14 vs. 44 +/- 19, P 0.0001 and 51 +/- 22 vs. 39 +/- 10, P 0.01, respectively) scores following treatment with tolterodine. CONCLUSIONS: This valid, reliable measure can be used in clinical practice and research trials to measure urgency severity.
Keywords: Adult; Aged; Aged, 80 and over; Female; Humans; Middle Aged; Obstetrics and Gynecology; Severity of Illness Index; Questionnaires; Reproducibility of Results; Quality of Life; Benzhydryl Compounds/therapeutic use; Cresols/therapeutic use; Muscarinic Antagonists/therapeutic use; Phenylpropanolamine/therapeutic use; Urinary Bladder, Overactive/drug therapy/physiopathology
Journal Title: International Urogynecology Journal
Volume: 23
Issue: 2
ISSN: 0937-3462
Publisher: Unknown  
Journal Place: England
Date Published: 2012
Start Page: 193
End Page: 196
Language: eng
DOI/URL:
Notes: LR: 20121115; JID: 101567041; 0 (Benzhydryl Compounds); 0 (Cresols); 0 (Muscarinic Antagonists); 14838-15-4 (Phenylpropanolamine); WHE7A56U7K (tolterodine); 2011/03/26 [received]; 2011/07/21 [accepted]; 2011/08/18 [aheadofprint]; ppublish