The relationship between reticulated platelets, intestinal alkaline phosphatase, and necrotizing enterocolitis Journal Article


Authors: Kampanatkosol, R.; Thomson, T.; Habeeb, O; Glynn, L.; DeChristopher, P. J.; Yong, S.; Jeske, W; Maheshwari, A.; Muraskas, J.
Article Title: The relationship between reticulated platelets, intestinal alkaline phosphatase, and necrotizing enterocolitis
Abstract: BACKGROUND: Necrotizing enterocolitis (NEC) affects up to 10% of extremely-low-birthweight infants, with a 30% mortality rate. Currently, no biomarker reliably facilitates early diagnosis. Since thrombocytopenia and bowel ischemia are consistent findings in advanced NEC, we prospectively investigated two potential biomarkers: reticulated platelets (RP) and intestinal alkaline phosphatase (iAP). METHODS: Infants born 0 U/L) in at least one sample before onset. Infants with "low" RP were significantly more likely to develop NEC [HR=11.0 (1.4-83); P=0.02]. Infants with "high" iAP were at increased risk for NEC, although not significant [HR=5.2 (0.7-42); P=0.12]. Median iAP levels were significantly higher at week 4 preceding the average time to NEC onset by one week (35.7+/-17.3days; P=0.02). CONCLUSION: Decreased RP serves as a sensitive marker for NEC onset, thereby enabling early preventative strategies. iAP overexpression may signal NEC development.
Keywords: Biomarker; Extremely-low-birthweight; Necrotizing enterocolitis; Premature; Pediatric Surgery
Journal Title: Journal of pediatric surgery
Volume: 49
Issue: 2
ISSN: 1531-5037; 0022-3468
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2014
Start Page: 273
End Page: 276
Language: eng
DOI/URL:
Notes: CI: Copyright (c) 2014; GR: R01 HD059142/HD/NICHD NIH HHS/United States; JID: 0052631; OTO: NOTNLM; 2013/11/01 [received]; 2013/11/10 [accepted]; 2013/11/21 [aheadofprint]; ppublish