Anticoagulant and Antithrombotic Actions of AVE5026, an Enriched Anti-Xa Hemisynthetic Ultra-Low-Molecular-Weight Heparin Journal Article


Authors: Hoppensteadt, D. A.; Gray, A; Jeske, W. P.; Walenga, J. M.; Fareed, J
Article Title: Anticoagulant and Antithrombotic Actions of AVE5026, an Enriched Anti-Xa Hemisynthetic Ultra-Low-Molecular-Weight Heparin
Abstract: Introduction: AVE5026 represents a new generation of ultra-low-molecular-weight heparin (LMWH) with high anti-Xa and low anti-IIa activities (anti Xa-IIa ratio >30). In addition, AVE5026 exhibits a relatively higher proportion of AT components. Materials and Methods: The anticoagulant, antiplatelet, antithrombotic, and bleeding effects of AVE5026 in comparison to other heparins were investigated in this study. Results: AVE5026 demonstrated weak effects in the global clotting assays; however, in the amidolytic anti-Xa assay, AVE5026 produced strong inhibitory effects. AVE5026 showed no cross-reactivity with the heparin-induced thrombocytopenia antibodies in the platelet aggregation system. AVE5026 produced a dose-dependent antithrombotic response after intravenous (IV) and subcutaneous (SC) administration in thrombosis models. The relative bleeding effects of AVE5026 in a rat tail bleeding and rabbit blood loss model were negligible after both IV and SC administration. Conclusions: This superior safety efficacy index in animal models in comparison with other LMWH may translate into improved antithrombotic efficacy with decreased bleeding risk.
Keywords: Safety; antithrombotic; bleeding; enriched anti-Xa activity; ultra-low-molecular-weight heparin
Journal Title: Clinical Applied Thrombosis/Hemostasis
Volume: 20
Issue: 6
ISSN: 1938-2723
Publisher: Unknown  
Date Published: 2014
Start Page: 621
End Page: 628
Language: ENG
DOI/URL:
Notes: JID: 9508125; 2013/03/11 [aheadofprint]; aheadofprint