Paget's disease of bone Journal Article

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Authors: Gruener, G; Camacho, P
Article Title: Paget's disease of bone
Abstract: Paget's disease is an osteoclastic-mediated disorder of bone that results in abnormal bone resorption associated with inadequate remodeling that leads to mechanically weakened bone. Demonstrating variable geographic prevalence, it is becoming less frequent and age of onset is lengthening in areas of once high prevalence prior to the institution of effective medical therapies, suggesting its etiology involves both environmental as well as genetic factors. Insights into its pathophysiology are helping to clarify other inherited osteolytic disorders of bone by providing additional insights into related cellular processes.
Journal Title: Handbook of clinical neurology
Volume: 119
ISSN: 0072-9752; 0072-9752
Publisher: Unknown  
Journal Place: Netherlands
Date Published: 2014
Start Page: 529
End Page: 540
Language: eng
DOI/URL:

10.1016/B978-0-7020-4086-3.00034-5

10.1016/B978-0-7020-4086-3.00034-5
Notes: CI: (c) 2014; JID: 0166161; OTO: NOTNLM; ppublish