Specifying protein kinase C functions in melanoma Journal Article


Author: Denning, M. F.
Article Title: Specifying protein kinase C functions in melanoma
Abstract: The protein kinase C (PKC) family of serine/threonine protein kinases is a heterogeneous group of enzymes receiving and integrating signals involved in both normal melanocyte biology and melanoma pathology. Alterations in PKC enzyme expression and activation contribute to the malignant phenotype of melanoma in both oncogenic and tumor suppressive roles. Delineating the diverse and often context-dependent functions of PKC enzymes in melanocyte/melanoma biology is key to capitalize on these kinases as drug targets. This review summarizes several of the diverse functions of PKC in melanocyte and melanoma biology with a focus on PKC enzyme regulation and function. Copyright 2012 John Wiley Sons A/S.
Keywords: Humans; Pathology; Animals; Enzyme Activators; Genetic Heterogeneity; Melanoma; Protein Kinase C; Protein Kinase Inhibitors; Skin Neoplasms
Journal Title: Pigment cell melanoma research
Volume: 25
Issue: 4
ISSN: 1755-148X; 1755-1471
Publisher: Wiley Periodicals, Inc  
Journal Place: England
Date Published: 2012
Start Page: 466
End Page: 476
Language: English
DOI/URL:
Notes: ID: 12587; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; [Review]; Publishing Model: Journal available in: Print Citation processed from: Internet; NLM Journal Code: 101318927; CAS Registry/EC Number/Name of Substance: 0 (Enzyme Activators). 0 (Protein Kinase Inhibitors). EC 2-7-11-13 (Protein Kinase C).; Entry Date: 20121017