Thiazide Use is Associated with Reduced Risk for Incident Lower Extremity Fractures in Men with Spinal Cord Injury Journal Article


Authors: Carbone, L D; Chin, A. S.; Lee, T. A.; Burns, S. P.; Svircev, J. N.; Hoenig, H. M.; Bailey, L; Weaver, F M
Article Title: Thiazide Use is Associated with Reduced Risk for Incident Lower Extremity Fractures in Men with Spinal Cord Injury
Abstract: OBJECTIVES: To determine the association between thiazide use and lower extremity fractures in male patients with a Spinal Cord Injury (SCI). DESIGN: Cohort Study from Fiscal Year (FY) 2002-2007. SETTING: Veterans Affairs (VA) Medical Centers. PARTICIPANTS: 6,969 men with SCI from the VA SCD (Spinal Cord Dysfunction) Registry including 1,433 users of thiazides and 5,536 nonusers of thiazides. INTERVENTIONS: Thiazide use vs. nonuse. MAIN OUTCOME MEASURE: Incident lower extremity fractures. RESULTS: 21% of men in the VA SCD Registry (FY2002-FY2007) included in these analyses used thiazide diuretics. There were 832 incident lower extremity fractures over the time period of this study: 110/1433 (7.7%) in thiazide users and 722/5536 (13.0%) in non- users of thiazides. In unadjusted and adjusted models alike, thiazide use was associated with at least a one-quarter risk reduction in lower extremity fracture at any given point in time (unadjusted: HR 0.75, 95% CI 0.59-0.94; adjusted: HR 0.74, 95% CI 0.58-0.95). CONCLUSIONS: Thiazide use is common in men with SCI and is associated with a decreased likelihood for lower extremity fractures.
Keywords: General Internal Medicine; BZDs; Benzodiazepines; FY; Fiscal Year; ICD-9; IRBs; Institutional Review Boards; International Statistical Classification of Diseases, 9th revision; JNC; Joint National Committee; SAS; SCD; SCI; SSRIs; Serotonin receptor agonists; Spinal Cord Dysfunction; Spinal Cord Injury; Statistical Analysis System; VA; Veterans Affairs; fractures; men; thiazides
Journal Title: Archives of Physical Medicine and Rehabilitation
ISSN: 1532-821X; 0003-9993
Publisher: Elsevier Inc  
Date Published: 2013
Language: ENG
DOI/URL:
Notes: CI: Copyright (c) 2013; JID: 2985158R; OTO: NOTNLM; 2013/07/25 [received]; 2013/12/12 [revised]; 2013/12/13 [accepted]; aheadofprint
LUC Authors
  1. Frances M Weaver
    53 Weaver
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