Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzle Journal Article

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Authors: Boccardi, M.; Bocchetta, M; Aronen, H. J.; Repo-Tiihonen, E.; Vaurio, O.; Thompson, P. M.; Tiihonen, J.; Frisoni, G. B.
Article Title: Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzle
Abstract: Psychopathy has been associated with increased putamen and striatum volumes. The nucleus accumbens - a key structure in reversal learning, less effective in psychopathy - has not yet received specific attention. Moreover, basal ganglia morphology has never been explored. We examined the morphology of the caudate, putamen and accumbens, manually segmented from magnetic resonance images of 26 offenders (age: 32.5 +/- 8.4) with medium-high psychopathy (mean PCL-R=30 +/- 5) and 25 healthy controls (age: 34.6 +/- 10.8). Local differences were statistically modeled using a surface-based radial distance mapping method (p0.05; multiple comparisons correction through permutation tests). In psychopathy, the caudate and putamen had normal global volume, but different morphology, significant after correction for multiple comparisons, for the right dorsal putamen (permutation test: p=0.02). The volume of the nucleus accumbens was 13% smaller in psychopathy (p corrected for multiple comparisons 0.006). The atypical morphology consisted of predominant anterior hypotrophy bilaterally (10-30%). Caudate and putamen local morphology displayed negative correlation with the lifestyle factor of the PCL-R (permutation test: p=0.05 and 0.03). From these data, psychopathy appears to be associated with an atypical striatal morphology, with highly significant global and local differences of the accumbens. This is consistent with the clinical syndrome and with theories of limbic involvement.
Journal Title: International journal of law and psychiatry
Volume: 36
Issue: 2
ISSN: 1873-6386; 0160-2527
Publisher: Elsevier Inc  
Journal Place: Netherlands
Date Published: 2013
Start Page: 157
End Page: 167
Language: eng
DOI/URL:

10.1016/j.ijlp.2013.01.008

10.1016/j.ijlp.2013.01.008
Notes: CI: Copyright (c) 2013; GR: AG020098/AG/NIA NIH HHS/United States; GR: EB008281/EB/NIBIB NIH HHS/United States; GR: P41 EB015922/EB/NIBIB NIH HHS/United States; GR: R01 AG020098/AG/NIA NIH HHS/United States; GR: R01 EB008281/EB/NIBIB NIH HHS/United States; GR: RR013642/RR/NCRR NIH HHS/United States; JID: 7806862; NIHMS437810; OID: NLM: NIHMS437810 [Available on 03/01/14]; OID: NLM: PMC3603572 [Available on 03/01/14]; PMCR: 2014/03/01 00:00; 2013/02/08 [aheadofprint]; ppublish