Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature Journal Article

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Authors: Argyris, P. P.; Pambuccian, S. E.; Cayci, Z.; Singh, C; Tosios, K. I.; Koutlas, I. G.
Article Title: Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature
Abstract: Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation ("dedifferentiation"). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with "ductal" differentiation, in the case presented, the "dedifferentiated" component showed morphologic and immunohistochemical features of myoepithelial differentiation.
Journal Title: Head and neck pathology
Volume: 7
Issue: 1
ISSN: 1936-0568
Publisher: Unknown  
Journal Place: United States
Date Published: 2013
Start Page: 85
End Page: 92
Language: eng
DOI/URL:

10.1007/s12105-012-0383-2

10.1007/s12105-012-0383-2
Notes: JID: 101304010; OID: NLM: PMC3597153; 2012/05/17 [received]; 2012/06/29 [accepted]; 2012/07/25 [aheadofprint]; ppublish